Ipamorelin stimulates selective growth hormone production and is a ghrelin receptor agonist. Ghrelin is a hormone produced by enteroendocrine cells (specialized cells found in the gastrointestinal tract, stomach, and pancreas) of the gastrointestinal tract that is often referred to as the “hunger hormone,” as it increases the urge to eat. Ghrelin helps prepare for food intake by increasing gastric motility (the movement of food through the stomach and into the intestines, which is controlled by muscles in the stomach and the enteric nervous system) and stimulating the secretion of gastric acid.

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Ipamorelin binds to ghrelin receptors, stimulates the release of somatocrinin (a hormone released by the hypothalamus which induces the growth of human growth hormone), and inhibits somatostatin (growth hormone-inhibiting hormone that regulates the endocrine system and affects neurotransmission and cell proliferation) and suppresses its action.

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It is best known for its lean muscle-growing benefits, as well as fat burning effects, accelerating injury recovery, and as an anti-aging peptide.

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Muscle Growth and Maintenance

• Stimulates the pituitary gland and mimics the body’s natural release of growth hormone and ghrelin

• Promotes the growth of lean muscle by increasing collagen levels and promoting muscle regeneration

• Prevents muscle-wasting whether caused by aging or medication

• Safe for long-term use due to minimal impact on acetylcholine, prolactin, cortisol, or aldosterone

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Promotes Healthy Bones

• Increases bone density and bone mineral content

• Supports bone formation, growth, and longitudinal development

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Metabolic and Digestive Benefits

• Enhances metabolism and burns fat

• Improves gut health, protects against ulcers, and improves gastric tissue health

• Accelerates gastric emptying and GI tract function

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Enhances Recovery and Regeneration

• Supports cartilage repair via chondrogenesis

• Improves collagen synthesis and healing of injured tissues

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Strengthens the Immune System

• Increases white blood cells, T-cells, and B-cells

• Reduces inflammation and improves phagocyte activity

• Corrects metabolic states caused by disease

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Prevents Cognitive Decline

• Improves cognitive function and protects brain cells

• Prevents age-related dopamine loss tied to Alzheimer’s and Parkinson’s

• Boosts memory and problem-solving skills

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Additional Benefits

• Improves cardiovascular function

• Regulates blood sugar

• Increases libido and combats erectile dysfunction

• Boosts estrogen and sexual desire in women

• Enhances sleep by promoting deep (slow-wave) sleep

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Possible Side Effects

• Injection site reactions

• Dry mouth

• Headache

• Nausea

• Vomiting

• Increased hunger

• Hyperactivity

• Drowsiness

• Skin flushing

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Rare Side Effects

• Changes in taste

• Difficulty swallowing

• Chest tightness

• Hives

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USE WITH CAUTION/UNDER CLOSE MEDICAL SUPERVISION

• Uncontrolled diabetes or severe insulin resistance

• Personal history of cancer

• Intracranial lesions/pituitary tumors

• Untreated hypothyroidism

• Severe cardiovascular disease

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CONTRAINDICATIONS (ABSOLUTE)

• Active malignancy (can promote tumor growth in solid tumors, hematologic malignancies, active cancer under treatment)

• Do not use if you are pregnant or breastfeeding

• Current or suspected neoplasia

• Can worsen retinal neovascularization

• Do not take if you determine that you are hypersensitive or allergic to Ipamorelin

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